Composition :
Each Bolus contains -
- Sulfadiazine BP .........1.666 gm
- Sulfadimidine BP....... 1.666 gm
- Sulfapiridine BP.......... 1.666 gm
Sulfadiazine, Sulfadimidine & Sulfapiridine
Each Bolus contains -
PABA (Para amino benzoic acid) is essential for bacterial growth & multiplication (synthesized by bacteria & supplied from the environment). By different enzymatic processes PABA is converted into Dihydrofolic acid at first & then Tetrahydrofolic acid. Tetrahydrofolic acid acts as a co-factor for single carbon metabolism & Nucleic acid synthesis. But due to structural similarity of PABA with Sulfonamides Dihydropteridin (essential for dihydrofolic acid synthesis) mistakenly combined with Sulfonamides instead of PABA. As a result Dihydrofolic acid synthesis is prevented. As a result bacterial DNA synthesis is interrupted. Sulfonamides are bacteriostatic in action.
It is used for organisms which are sensitive to Sulfonamides. E.g. – Pneumonia, Haemorrhagic Septicemia, Calf Diphtheria, Secondary bacterial infection in case of FMD, Navel ill, Dehorning, Castration, Urinary tract infection, Metritis, Arthritis, Tonsillitis in a dog, Paratyphoid, Distemper etc.
Should not be used for the animal hypersensitive to Sulfonamide.
1 bolus / 35 kg body weight on first day and followed by half dose ( ½ bolus / 35 kg b. wt. / day) for next 3 – 5 consecutive days. Administer orally through drinking water or feed (by mixing with molasses, wrapped with banana leaf).
Adequate drinking water should be given during the treatment of the animal. In the case of kidney-deformed animals, close observation is very essential to avoid crystal urea formation. Treatment should be stopped in case of severe hypersensitivity.
Meat: 10 days,
Milk: 4 days
Each box contains 5 x 4’s Boli in blister strip.
