Composition :
Each bolus contains:
• Sulfadiazine BP ………………….1.583 gm
• Sulfadimidine BP…….………….1.583 gm
• Sulfapiridine BP………………….1.583 gm
• Streptomycin Sulphate BP…. 0.3132 gm (as 0.25 Streptomycin base)
Sulfadiazine, Sulfadimidine, Sulfapiridine, and Streptomycin Sulphate
Each bolus contains:
• Sulfadiazine BP ………………….1.583 gm
• Sulfadimidine BP…….………….1.583 gm
• Sulfapiridine BP………………….1.583 gm
• Streptomycin Sulphate BP…. 0.3132 gm (as 0.25 Streptomycin base)
PABA (Para amino benzoic acid) is essential for bacterial growth & multiplication (synthesized by bacteria & supplied from the environment). By different enzymatic processes PABA is converted into Dihydrofolic acid at first & then Tetrahydrofolic acid. Tetrahydrofolic acid acts as a co-factor for single carbon metabolism & Nucleic acid synthesis. But due to the structural similarity of PABA with Sulfonamides Dihydropteridin (essential for dihydrofolic acid synthesis) mistakenly combined with Sulfonamides instead of PABA. As a result, Dihydrofolic acid synthesis is prevented. As a result, bacterial DNA synthesis is interrupted. Sulfonamides are bacteriostatic in action.
Streptomycin binds to the 30s subunit of the bacterial ribosome as a result interferes with several mechanisms in the mRNA translation process. It also interferes with the initiation of DNA replication. These conditions are responsible for the bactericidal effect. Streptomycin is especially effective against enteric pathogens such as Escherichia coli.
It is used for the treatment of diseases in cattle, horses, sheep & goats caused by organisms sensitive to Sulfonamides & Streptomycin. E.g. – Diarrhoea, dysentery, enteritis, calf scours, coccidiosis in calf, etc.
Should not be used for the animal hypersensitive to Sulfonamide & Streptomycin. And also should not be used in case of renal impairment.
1 bolus / 35 kg body weight on the first day and followed by half dose (½ bolus / 35 kg b. wt. / day) for the next 3 – 5 consecutive days. Normally 2 – 3 days of treatment is sufficient. Treatment may continue up to 7 days in case of secondary bacterial complications. Administer orally through drinking water or feed (by mixing with molasses, wrapping with banana leaf).
Or, as prescribed by the Registered Veterinary Physician.
Comparatively, it has no side effects at the recommended dose. But prolonged treatment may cause Agranulositosis, Haemolytic anemia & Vit-K deficiency in the body.
Close observation should be needed in case of prolonged treatment. Adequate drinking water should be given during the treatment of the animal in case of dehydration. Avoid contact with the skin due to component Streptomycin.
Store at a temperature below 25 ⁰C, protect from light & keep in a dry and cool place. Keep all medicines out of reach of children.
Each box contains 4X5’s bolus in blister strip.
